Heart failure drug less effective in real world
A large study addressing the effectiveness and safety of aldosterone antagonist therapy for older heart failure patients has found notable differences between the drug's results in clinical trial vs....
View ArticleStudies examine whether therapies for heart failure are associated with...
An analysis of two heart failure therapies finds differing outcomes regarding improvement in survival, according to two studies appearing in the November 28 issue of JAMA.
View ArticleSABCS: no benefit in extending trastuzumab in HER2 breast CA
(HealthDay)—For patients with human epidermal growth factor receptor 2 (HER2)-positive early-stage breast cancer, one year of adjuvant trastuzumab should remain the standard of care, according to a...
View ArticleGene therapy reprograms scar tissue in damaged hearts into healthy heart muscle
A cocktail of three specific genes can reprogram cells in the scars caused by heart attacks into functioning muscle cells, and the addition of a gene that stimulates the growth of blood vessels...
View ArticleGene therapy may activate stem cells in heart failure patients
(HealthDay)—Delivery of an SDF-1 encoding plasmid (JVS-100) acts a homing signal for stem cells and improves clinical status in patients with symptomatic heart failure due to ischemic cardiomyopathy...
View ArticleLong-term use of medication does not improve symptoms for heart failure patients
Among patients with heart failure with preserved ejection fraction, long-term treatment with the medication spironolactone improved left ventricular diastolic function but did not affect maximal...
View ArticleScarring of heart muscle linked with increased risk of death in patients with...
Detection of midwall fibrosis (the presence of scar tissue in the middle of the heart muscle wall) via magnetic resonance imaging among patients with nonischemic dilated cardiomyopathy (a condition...
View ArticleShock teams and ECMO save lives in massive STEMI
The use of extracorporeal membrane oxygenation (ECMO), accompanied by mechanical CPR, in patients with massive myocardial infarctions can lead to unexpected survival. These study findings are being...
View ArticleCombination therapy for heart failure does not reduce risk of CV death or...
Among patients hospitalized for heart failure (HF) with reduced left ventricular ejection fraction (LVEF; a measure of how well the left ventricle of the heart pumps with each contraction), initiation...
View ArticleSildenafil for heart failure does not result in significant improvement in...
Among patients with heart failure with preserved ejection fraction (a measure of heart function), administration of sildenafil (commercially known as Viagra) for 24 weeks, compared with placebo, did...
View ArticleDigoxin reduces hospital admissions in older patients with chronic heart failure
Digoxin significantly reduces the likelihood of hospital admission due to all causes among ambulatory older patients with chronic heart failure and reduced ejection fraction (HFrEF), according to...
View ArticleCardiac function unaffected by prior intensive insulin therapy
(HealthDay)—There was no effect of intensive versus conventional insulin therapy during the Diabetes Control and Complications Trial (DCCT) on cardiac parameters as assessed by cardiac magnetic...
View ArticleOutcomes for treating heart failure with cell therapy, high-dose ultrasound
Treatment that consisted of shock wave (procedure using high-dose ultrasound)-mediated preconditioning of the target heart tissue prior to administration of bone marrow-derived mononuclear cells was...
View ArticleDeath rates decline for advanced heart failure patients, but outcomes are...
UCLA researchers examining outcomes for advanced heart-failure patients over the past two decades have found that, coinciding with the increased availability and use of new therapies, overall mortality...
View ArticleFeasibility trial reports deployment of new device for TAVI in aortic...
A new investigational device - the Helio System (TF-FA) - being developed for use with the Sapien XT Transcatheter Heart Valve was successfully deployed in all four patients in a small, first-in-human...
View ArticleRELAX-AHF shows first positive findings in HFpEF patients
Serelaxin may be more effective for relieving dyspnea in heart failure with preserved ejection fraction (HFpEF) than reduced (HFrEF) during the first 24 hours, according to results from RELAX-AHF...
View ArticleLiving better with heart failure by changing what you eat
Diet can dramatically lower hypertension and improve heart function in patients with a common type of heart failure, according to research presented at today's Heart Failure Society of America meeting...
View ArticleNew study shows spironolactone reduces heart failure hospitalizations, but...
A late-breaking clinical trial, known as the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial, to be presented at the American Heart Association (AHA)...
View ArticleTwo drugs do not improve kidney function in acute heart failure patients
Two drugs tested in a larger trial did not improve kidney function in acute heart failure patients, contrary to results of smaller studies. The results were presented today at the American Heart...
View ArticleStudy identifies new way to predict prognosis for heart failure patients
Johns Hopkins researchers have identified a new way to predict which heart failure patients are likely to see their condition get worse and which ones have a better prognosis. Their study is one of the...
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